Talk:Weapons/@comment-73.212.247.86-20151129163049/@comment-24055167-20151129175421

Both. As you skip the chests it means that the large chest will appear in a later area which at the same time means it will have weapons that start droping in that area. At the same time every Weapon Chest you skip adds 25% chance that a large weapons spawns in the next level. I believe all of this is said in the Large Weapon Chest's description on the Pickups/Props page.